authorJustine Adams, Li-yin Goh, Alannah Rudkin

The POPCORN study is a novel embedded clinical trial comparing post-op nausea and vomiting in pediatric patients using patient-controlled analgesia (PCA) with morphine versus oxycodone.

This study seeks to identify the preferred opioid (morphine or oxycodone) for postoperative pediatric patients using patient-controlled analgesia (PCA) by comparing their impact on nausea and vomiting, ultimately optimizing patient comfort and recovery.

The trial will involve randomising patients to either Oxycodone or Morphine for PCA. The EMR will automatically identify potentially suitable patients and routinely collected data will be extracted for analysis. The study focuses specifically on children between 6-18 years of age undergoing surgical procedures and require a PCA.

This multisite study will be conducted in Victoria and Queensland and the research will span two years, allowing for comprehensive data collection and analysis.